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  • Fumaric acid for psoriasis treatment.

    The problem with psoriasis is that there is relief but no permanent cure available. Modern science does not know exactly what causes this skin condition, even though it was associated with allergies, arthritis, and various dietary and metabolic factors. There are many topical treatments available for those who have psoriasis. Treatments made with chemicals, antibitics, hormone therapies and treatments based on all natural ingredients

    There is an increased evidence that fumaric acid might help to keep psoriasis under control. This treatment involves the use of fumaric acid ester, commonly used in the food industry as a food additive in place of citric acid. In healthy individuals, fumaric acid is formed in the skin when it's exposed to sunlight. People with psoriasis appear to have a biochemical defect that requires prolonged exposure to the sun to produce it. Fumaric acid ester capsules have been used in clinical trials in Switzerland and the Netherlands with excellent results. In a recent study, 8O percent of the 285 patients involved reported marked improvement, and 52 percent of those patients were completely cleared of psoriatic lesions.

    Treatment of psoriasis with fumaric acid is a long process it might take up to three months before one can see improvement. Eventhough the treatment is effective, it has not only severe side effects but as all oral medications, it also looses more than 75% of its strength in the process. Higher dosage of fumaric acid will lead to more side effects.

    Eventhough, the technology of administration (oral ingestion) remained mostly the same till now. One well established, yet incompletely developed delivery mode has been topical creams and lotions, primarily utilized in cosmetic applications. The great barrier to wider application of such a pathway has been the structure of the skin itself, which has proven impermeable to a wide range of compounds, most notably the class of molecules know as "water soluble". This limitation has so strongly influenced perception of range restriction of compound delivery across the skin.

    But now, through the research conducted by group of American scientists this border has been unlocked and opened to transdermal traffic of virtually all medicinal compounds. The mechanics of this invention allows to create a triple emulsion that creates an unusually stable matrix into which nutrient compounds can be fed. The emulsion was named "Liquid Crystal". This refers to the creation, through the "microencapsulation" of molecules of the active ingredients in the emulsion, of actual liquid crystals in a state of stable suspension. This special physical configuration has the effect of making large molecules behave, in relation to the skin barrier, as though they are "smaller", and allowed to cross what would otherwise prevent penetration.

    An important aspect of this technology is the efficiency factor. Active ingredients can target the problem areas directly instead of going through digestive system, as oral medication, loosing more than 75% of its strength in the process. In other words, "Liquid Crystal" allows for great reduction in dose levels of any given substance compared to oral administration in our case - level of fumaric acid in psoriasis treatment. Reduction of excess compounds of any kind, even biologically compounds, is always the soundest medical approach, and becomes imperative when any substances that a person may have sensitivity to is being administered.

    Read more about fumaric acid psoriasis treatment wich was made with use of this unique - patented technology.

    02 October 2006, 22:36
    Admin
    Any psoriasis sufferers who had treatment with Fumaderm - Fumaric acid and would like to share their stories, discuss the treatment please post it here. Also we welcome your comments on Ovante psoriasis cream which has fumaric acid in its ingredients.
    03 October 2006, 23:22
    Re: Fumaric acid and pi
    Greetings all,
    Incredible article Ovante! I red it last night and did some research on Fumaderm and use of fumaric acid in general.
    Here is what i think all you should know about this stuff before taking it oraly:
    Fumaderm (Fumaric Acid Esters), is a medication which combines two fumaric acid esters (FAEs) - monoethylfumarate (MMF) and dimethylfumarate (DMF). FAEs have been used to treat psoriasis for over 30 years. Fumaderm is the leading prescription for oral systemic treatment of moderate-to-severe psoriasis in Germany and some other European nations.
    Side effects of this therapy include nausea, gastro-intestinal problems, diarrhea, and kidney disorders. Decreased white blood cell count has also been reported. These side effects are however reversible with the withdrawal of treatment.
    A new product which is being developed by the pharmaceutical company Biogen (BG-12 oral fumarate) contains only one fumaric acid ester and appears to produce fewer gastrointestinal symptoms. BG-12 oral fumarate is currently undergoing clinical trials in the United States.
    Very interesting that is Germany's number one treatment for P but there is no licence for it's use in the UK. Germany has some 30 years experience of it's use. Side effects are said to be minimal and it's success rate impressive.
    It is remarkable what you guys at Ovante did with fumaric acid, i mean the technology and the idea itself of minimizing side effects and increasing effectiveness of treatment by not takin this drug oraly but by applying it directly to the skin. I think it is marvelous technology.
    Has anyone here had any experience of Fumaric Acid Esters ? How about Ovante psoriasis cream? Has anyone tried their cream?
    Sam
     
    06 October 2006, 00:41
    FUMADERM
     Twenty years following the establishment of Fumapharm AG, and nine years after approval of FUMADERM in Germany, -- one of the most innovative and leading companies in the worldwide pharmaceutical market -- on the further development of our improved fumarate derivative," said Dr. Hans Peter Strebel, President and CEO of Fumapharm.
    "Biogen and Fumapharm will work closely together to fully utilize the potential of this promising product with the goal of providing a successful therapy directed initially to treat psoriasis patients worldwide. This license agreement provides not only the resources, but also combines the know- how necessary to conduct all stages of research, development and marketing. Fumapharm and Biogen are well under way to define the future together," Dr. Strebel said.
    About Biogen

    About Fumapharm AG
    Fumapharm is a privately held pharmaceutical company headquartered in Lucerne, Switzerland.
    FUMADERM(R) is the leading oral prescription drug for systemic treatment of moderate-to-severe psoriasis in Germany. For more information, please visit
    http://fumapharm.ch


    Anonymous
    16 June 2008, 00:48
    Fumaderm again
    I had been using fumaderm for a while now, it is possible to get with a prescrpiption here in Germany. Effects are pretty good but only sertain time of year and i think the weather also affects it

    Stan
    22 June 2008, 22:31
    Fumaric acid in the US
    I read a lot on internet and on the News that in Europe fumaric acid treatment in the form of fumaric acid tablets are very popular. The fumaric acid treatments overthere come as ointments, lotions even tablets and scalp lotions. They widely used to reverse symptoms of psoriasis and i red about many sucsessful stories while traveling to Europe last month. I was wondering when is the Fumaric acid treatments will become available here in the US?
    Any comments???


    Martin

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